The primary goal of this study was to improve the solubility rate of atazanavir sulphate, which in turn would increase dissolution, or the rate of drug release, resulting in increased drug absorption. The approach used here was effervescent-assisted fusion. Various batches were made using a water soluble carrier and sodium bicarbonate. The study's findings demonstrated that the medication's solubility in several solvents, including phosphate buffer and distilled water, may be improved by up to tenfold when compared to pure drug. The compatibility investigation revealed no contact between the medicine and the excipient, while the micromeretics property demonstrated good flow and compressibility properties. The produced dispersions had a percent yield ranging from 79.20±0.28% to 89.38±0.25%, with a higher rate of drug release than pure drugs (10.87%-99.14%). The pure drug had a drug release of less than 70%, but the optimized batch F5 had a drug release of more than 95% within the specified time frame. The XRD data demonstrated that the drug's crystalline structure was not impeded throughout the preparation, but the SEM data disclosed the surface shape of the pure drug, which was tile-shaped and the created dispersion, which was flakes-like in formation. The study concluded that the procedures used in this investigation were effective in increasing the drug's solubility by up to tenfold.
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